CRISPR-ABEmax mRNA for High-Precision Adenine Base Editing

Croyez offers CRISPR-ABEmax mRNA in both unmodified and m1Ψ-modified formats to support high-precision adenine base editing across diverse research applications.
ABEmax is a second-generation adenine base editor that enables efficient and precise A-to-G (A-to-I) conversions in genomic DNA without introducing double-strand breaks.

Both ABEmax mRNA formats are produced by in vitro transcription (IVT) and feature a Cap 1–modified 5′ end and a poly(A) tail at the 3′ end, allowing rapid, transient protein expression directly in the cytoplasm without the need for nuclear entry. This design minimizes off-target effects and ensures predictable editing performance.

• Unmodified ABEmax mRNA is well-suited for standard genome-editing studies, functional genomics, and screening workflows where robust expression is required.

• m1Ψ-modified ABEmax mRNA incorporates modified nucleotides to reduce innate immune activation, offering enhanced stability and improved expression consistency—ideal for sensitive cell types or advanced research models.

Together, Croyez’s ABEmax mRNA solutions provide researchers with flexible options for CRISPR base editing, gene function studies, genetic disease research, and preclinical therapeutic development.

• ABEmax mRNA Biocompare
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